Serbia's Novak Djokovic celebrates winning his French Open fourth-round match against Argentina's Francisco Cerundolo on Monday.

PARIS — An injured Novak Djokovic sealed a 15th consecutive French Open quarterfinal with a thrilling comeback victory over Argentinian Francisco Cerundolo in the fourth round on Monday, while Daniil Medvedev became the highest seed to crash out at Roland Garros so far.

In the women's draw, both Aryna Sabalenka and Elena Rybakina comfortably powered into the last eight.

A limping Djokovic looked to be heading for a shock defeat at two sets to one down and trailing 4-2 in the fourth, but he battled back from the brink to delight the Court Philippe Chatrier crowd by winning 6-1,5-7, 3-6, 7-5, 6-3 in four hours and 39 minutes.

"I was maybe three or four points away from losing this match," the reigning champion said. "I'm not sure how I won it."

Djokovic narrowly avoided his earliest exit from the tournament since 2009, teeing up a rematch of last year's final against Casper Ruud, who beat Taylor Fritz in four sets.

However, he said he was not yet 100 percent sure that he would be fit enough to play on Wednesday.

"I don't know what will happen tomorrow, or after tomorrow if I'll be able to step out on the court and play. I hope so. Let's see what happens," he said, before blaming his right knee injury on the unusually slippery courts.

"Could this injury have been prevented? Possibly," added Djokovic, who said he asked for the court to be swept more frequently.

Djokovic had reached the last 16 by defeating Italy's Lorenzo Musetti in another bruising five-set encounter which concluded at 3:07 am Sunday.

The 24-time Grand Slam title winner appeared to be feeling no ill-effects as he dominated the first set, but then needed a medical time-out early in the second after pulling up with an apparent knee injury.

The 37-year-old, eyeing a record 370th Grand Slam match win to break the tie with Roger Federer, played on, but continued to walk gingerly between points.

Cerundolo grabbed the second set by finally taking a break point after 12 previous misses.

The 23rd seed moved ahead by two sets to one against an increasingly frustrated top seed, before edging to the cusp of a famous win by forging 4-2 in front in the fourth set.

But, seemingly from nowhere, Djokovic dug deep to break and level it at 4-4.

He forced a decider on his fourth set point of a dramatic 12th game when a stretching Cerundolo could only find the net.

There appeared to be only one outcome on the cards when the Serbian star took a 2-0 advantage in the fifth, but his opponent rallied to level.

Djokovic was left covered in clay after a nasty tumble, sarcastically saying: "Well done supervisors, ground staff, everyone, the court is not slippery at all."

Fifth seed Medvedev suffered a four-set loss to Australia's Alex de Minaur, starting strongly before slipping to a 4-6, 6-2, 6-1, 6-3 defeat.

De Minaur will face Alexander Zverev in his second Slam quarterfinal and first since the 2020 US Open.

Zverev won his second successive five-setter, coming from behind to beat Holger Rune 4-6, 6-1, 5-7, 7-6 (2),6-2 in a night-session match which again finished in the early hours of the morning.

It was the second-latest finish in the tournament's history at 1:40 am, just two days after Djokovic and Musetti set the record.

The German world No 4 is playing under the cloud of an ongoing trial in Berlin over allegations of assaulting an ex-girlfriend.